Neurons, with their large cell bodies and extensive processes, depend on a delicately balanced intracellular transport machinery to keep in touch with their own outer reaches. Inequalities between ...

Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...

What Makes a Good Potential Target for Drug Discovery? Listen in as Dr Elizabeth Glennon, of King's College London, discusses how the disruption of axonal transports early on within Alzheimer's ...

As part of our investigation into axonal transport of AAV vectors, we conducted a survey of a number of AAV serotypes. In order to avoid confounding effects, we eliminated AAV vectors that were not ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

This is a preview. Log in through your library . Abstract βII-spectrin is the generally expressed member of the β-spectrin family of elongated polypeptides that form micrometer-scale networks ...

A protein linked to accumulation of harmful brain plaque in Alzheimer’s patients has been shown in fruit flies and mice to be an important part of a molecular transportation system that moves signals ...

This is a preview. Log in through your library . Abstract KIF1A is a kinesin superfamily motor protein that transports synaptic vesicle precursors in axons. Cargo binding stimulates the dimerization ...

A protein linked to accumulation of harmful brain plaque in Alzheimer’s patients has been shown in fruit flies and mice to be an important part of a molecular transportation system that moves signals ...