Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 37 (Sep. 12, 2006), pp. 13670-13675 (6 pages) The translocation of tRNA and mRNA through the ribosome is ...

GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. The basic reaction ...

microtubules are hollow cylinders consisting of tubulin, a heterodimer of α- and β-tubulin. In vivo microtubules are composed of 13 tubulin protofilaments, strings of consecutive αβ–αβ tubulin ...

Microtubules are active protein polymers critical to the structure and function of cells and the process of cell division. In a living cell their growing ends constantly elongate and retreat in a ...

GPCRs are by far the most extensively validated class of therapeutic targets, and there remains tremendous potential for targeting new receptors and their downstream effectors. GPCRs at the cell ...

Seeing, smelling, tasting, regulation of blood pressure – molecular switches are involved in all of these processes. The mechanism with which these proteins are switched off has been analysed by a ...

The Transcreener GTPase Assay Kit relies on direct detection of GDP produced by GTPases during GTP hydrolysis. The direct detection approach is a novel method to quantify activity of GTPases and their ...

Paediatric encephalopathies of genetic origin cause severe motor and intellectual disabilities from birth. One of these diseases, first identified in 2013, is caused by mutations in the GNAO1 gene. In ...