Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Scientists have ...

Scientists organize millions of proteins by shape, as predicted by AI, revealing 700,000 new families and some shapes unique ...

A significant step forward in protein design from Generate Biomedicines, Massachusetts, has developed an AI that can generate feasible protein structures and predict the potential functionality of the ...

The Human Domainome 1—the largest library of human protein variants—reveals the cause of certain genetic disorders, paving the way for personalized medicines. “We measured every possible mutation in ...

Most mutations that cause disease by swapping one amino acid out for another do so by making the protein less stable, according to a major study of human protein variants that was published in Nature ...

Proteins are most well-known for their intricate structures. The α-helices and β-sheets that form from interactions between sidechains create distinct shapes that, along with the specific amino acid ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...

To ensure that protein production in our cells runs smoothly, the protein complex NAC slows down the rate of protein ...

Microtubules perform an active role in communication within the cell by transmitting received signals to the cell's ...