Gene therapy has often been described as a “black box” technique; that is, it is not known what happens to the cell after vector-mediated gene transfer. Although expression levels of the transgene are ...
A significant limitation to the analytical accuracy and precision of dual-labeled spotted cDNA microarrays is the signal error due to dye bias. Transcript-dependent ...
Figure 1: cDNA microarray analysis of DNA copy-number changes. Figure 3: Genome-wide mapping of DNA copy-number variation for breast cancer cell line BT474. Figure 4: High-resolution analysis of ...
In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...
The main steps involved and limitations of microarray analysis will be encountered. Two stages can be distinguished in microarray experiments: a pre-microarray experiment phase (tissue handling) and ...
The Nottingham Prognostic Index (NPI) applied to 467 patients (pts) with a long-term follow-up that were treated in a single institution No significant financial relationships to disclose. This is an ...
Current microarray analysis uses 'chips' containing either 25-residue oligonucleotides synthesized by photolithography or cDNAs placed by robotic spotting. In the April Nature Biotechnology, Hughes et ...
Byung-IL Yoon, Guang-Xun Li, Kunio Kitada, Yasushi Kawasaki, Katsuhide Igarashi, Yukio Kodama, Tomoaki Inoue, Kazuko Kobayashi, Jun Kanno, Dae-Yong Kim, Tohru Inoue and Yoko Hirabayashi Although the ...
In those days, there were a limited number of known genes to select from. "The first thing you want is genes that have a name and activity associated with them, because if one of those is indicated as ...
You are oncologists specializing in breast cancer and will be conducting a microarray analysis on one of two newly diagnosed breast cancer patients, Mrs. Jones and Mrs. Brown. You will be adding a ...
Technology Set to Compete with Microarrays in This Application Arena Microarray-based gene-expression profiling technology hardly seems like it has been around long enough for a new approach to come ...
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